Yesterday marked the beginning of a new series of posts I am doing for the DeveloperForce Blog on .NET integration with Force.com. The first post, which you can find here goes over the differences between using a service reference versus a web reference when connecting to the Force.com SOAP API using .NET.
I actually discovered a surprise result when doing the research for this post, so if you work with.NET integration at all, I highly suggest you check it out.